PHARMATEK · Métabolisme

Estimation de la testostérone libre calculée selon Vermeulen

Calculer l’estimation brute du modèle de liaison 1:1 original de 1999 à partir de résultats sériques mesurés au même prélèvement de testostérone totale, de SHBG et d’albumine.

Révision clinique en cours

La révision clinique doit être complétée.

Cet outil fait partie de la bibliothèque PharmaTek. Son calcul reste indisponible au public jusqu’à la validation de sa formule, de ses limites et de ses sources.

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Sources, population et validation

État: clinical-review-pending
Version de la méthode: Original Vermeulen et al. 1999 one-to-one binding model, engine vermeulen-1999-original-1-to-1-free-testosterone-arithmetic-v1 reviewed 2026-08-13: N = 1 + (3.6 × 10^4 L/mol ÷ 69,000 g/mol) × measured albumin (g/L), then the numerically stable positive root cFT = 2T ÷ [N + SHBG − T + sqrt((N + SHBG − T)^2 + 4NT)] with measured total testosterone T and SHBG in nmol/L; raw unrounded cFT in nmol/L and pmol/L plus modelled free fraction only
Population: Clinician-directed adult arithmetic in exactly one of two narrow contexts: second-line androgen-status assessment in a symptomatic male after appropriately collected or repeated total testosterone, or androgen-excess assessment in a nonpregnant female. It requires age 18 or older and three final quantitative serum results from the same draw and laboratory: total testosterone in nmol/L by a validated LC-MS/MS method, SHBG in nmol/L by an explicitly validated method, and measured albumin in g/L with an explicit validated assay identity. Every result must be within its analytical measuring range and retain collection-date, laboratory, method, analyte, matrix, unit, and status provenance.
Limites et exclusions: Pregnancy; age under 18; acute illness; suspected binding-protein variant; competing or exogenous steroid contexts; oral testosterone, DHT, or mesterolone exposure; treatment monitoring; assumed, defaulted, stale, mixed-patient, mixed-draw, censored, qualitative, preliminary, analytically out-of-range, non-serum, unit-converted, or method-unverified inputs. · Substitution of equilibrium-dialysis measurement, another calculated-free-testosterone model, a fixed or default albumin value, alternative binding constants or stoichiometry, the Södergård, Ly, Zakharov, or modified-Vermeulen model, bioavailable testosterone, or a different laboratory calculator or range. · Reference intervals, cutoffs, flags, categories, normal or abnormal labels, diagnosis or exclusion of androgen deficiency or excess, probability, prognosis, treatment eligibility, monitoring target, dosing, management, recommendation, or comparison with another laboratory's reference interval or calculator. · The value is a modelled estimate rather than measured free testosterone. Published comparison with standardized equilibrium dialysis found systematic overestimation, and SHBG platform bias can materially move the estimate; assay- and method-specific results are not portable.

Origine de l’outil PharmaTek

Outil importé de la bibliothèque PharmaTek de MDose. Aucune date de révision clinique indépendante n’est documentée dans cette version.

Bibliothèque source: PharmaTek · MDose
Version importée: 4b66536936ed
État de publication: Révision clinique en cours

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