Calculateur du produit conventionnel non ajusté de Shine–Lal

État

clinical-review-pending

Version de la méthode

Conventional unadjusted Shine–Lal arithmetic v1: raw product = [mean corpuscular volume (MCV, fL)]² × mean corpuscular hemoglobin (MCH, pg) / 100; no component rounding; this two-input implementation deliberately omits the original 6.2% male score reduction, electrophoresis/genotype-AA branch, hemoglobin-A2 workflow, historical selection boundary, and all interpretation

Population

Adults for whom applicability of the historical ambulant-adult hemoglobinopathy-screening source context is independently established, using paired final quantitative MCV and MCH results from one contemporaneous complete blood count and the same EDTA venous whole-blood specimen, with exact analyte, analyzer, specimen, and fixed-unit identities verified. The original program tested 25,302 ambulant adults in Kentucky over three years and used additional sex-adjustment, electrophoresis/genotype, and hemoglobin-A2 stages that this arithmetic does not reproduce.

Limites et exclusions

The original 6.2% male score reduction, sex-category input or inference, electrophoresis or genotype-AA branch, hemoglobin-A2 measurement or workflow, variant-hemoglobin branching, historical selection boundary, threshold, sign rule, category, or screening conclusion. · Any carrier-status conclusion, alpha-versus-beta thalassemia inference, distinction between thalassemia and iron deficiency, diagnosis or exclusion, probability, predictive value, sensitivity or specificity claim, prognosis, reassurance, testing or genetic-counselling recommendation, management, treatment, or other clinical decision. · Pediatric or adolescent use, automatic population transfer, or extrapolation outside the historical ambulant-adult source context without independently established applicability. · Mismatched specimens or collection times, non-contemporaneous or nonfinal values, censored or inferred measurements, any specimen other than verified EDTA venous whole blood, unverified analyzer or analyte identity, unit conversion, inferred units, or units other than MCV in fL and MCH in pg.

• https://pubmed.ncbi.nlm.nih.gov/66486/
• https://doi.org/10.1016/S0140-6736(77)92128-6
• https://pubmed.ncbi.nlm.nih.gov/26536581/
• https://www.ncbi.nlm.nih.gov/books/NBK190467/

Outil importé de la bibliothèque PharmaTek de MDose. Aucune date de révision clinique indépendante n’est documentée dans cette version.

Bibliothèque source

PharmaTek · MDose

Version importée

4b66536936ed

État de publication

Révision clinique en cours