PHARMATEK · Fonction rénale

Calculateur adulte de la réabsorption du phosphate (TRP + TmP/DFG)

Calculer la TRP adulte brute et l’estimation algorithmique TmP/DFG de Kenny–Glen à partir de concentrations appariées vérifiées de plasma à jeun et de la deuxième miction du matin.

Révision clinique en cours

La révision clinique doit être complétée.

Cet outil fait partie de la bibliothèque PharmaTek. Son calcul reste indisponible au public jusqu’à la validation de sa formule, de ses limites et de ses sources.

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Sources, population et validation

État: clinical-review-pending
Version de la méthode: Adult TRP plus Kenny–Glen piecewise algorithmic TmP/GFR estimate v1: after separately normalizing paired phosphate and creatinine concentration identities, FEphosphate = (urine phosphate × plasma creatinine) / (plasma phosphate × urine creatinine) and TRP = 1 − FEphosphate; if raw TRP ≤ 0.86, algorithmic TmP/GFR = plasma phosphate × TRP; if raw TRP > 0.86, algorithmic TmP/GFR = plasma phosphate × [(0.3 × TRP) / (1 − 0.8 × TRP)]. Exact 0.86 uses the linear branch; the published rounded empirical branch discontinuity is retained without smoothing or clamping, with only a machine-precision comparison tolerance for unit-equivalent quantities. Phosphate accepts mmol/L or elemental-phosphorus mass mg/dL, plasma creatinine accepts µmol/L or mg/dL, and urine creatinine accepts mmol/L, µmol/L, or mg/dL using the shared NIST-derived conversions; outputs are raw and unrounded
Population: People age 19 years or older after a clinician independently establishes applicability of the adult protocol: fasting steady state; first morning urine discarded; second-morning void collected approximately two hours later according to local protocol; contemporaneous plasma collected in the same assessment before an intervening physiologic change or treatment; final quantitative inorganic-phosphate-as-phosphorus and creatinine concentrations obtained from the exact paired plasma and urine specimens; and specimen, analyte, assay, reported-unit, timing, handling, and local method compatibility verified. Use also requires acknowledging that plasma phosphate is assumed to represent filtrate phosphate and creatinine clearance is assumed to approximate GFR.
Limites et exclusions: Age under 19 years or any pediatric or adolescent use; serum in place of plasma; first-morning urine, timed or 24-hour urine, amounts per time, precomputed ratios, unmatched or non-contemporaneous specimens, collection outside the fasting second-morning protocol, or measurements separated by an intervening change or treatment. · Unverified specimen, analyte, assay, report, timing, handling, or unit identity; inferred units; whole-phosphate or phosphate-salt mass in place of elemental-phosphorus mass for mg/dL; mismatched phosphate or creatinine pairs; or silent unit reinterpretation. · Values producing TRP outside the mathematical domain from 0 through 1; clamping, smoothing, interpolating, categorizing, or clinically interpreting the empirical 0.86 branch point or the small published branch discontinuity. · A direct Tm measurement, measured GFR, exact or reproduced Walton–Bijvoet graphical nomogram result, laboratory reference interval, clinical threshold, result category, phosphate-wasting conclusion, diagnosis, probability, prognosis, replacement calculation, dose, management, treatment, or other clinical decision. · Treating the broad shared input/unit-error guardrails as laboratory reference ranges, validated population limits, or clinical decision thresholds; or claiming that this app validates assay bias or performance, specimen integrity, steady state, collection protocol, or the physiologic assumptions of the model.

Origine de l’outil PharmaTek

Outil importé de la bibliothèque PharmaTek de MDose. Aucune date de révision clinique indépendante n’est documentée dans cette version.

Bibliothèque source: PharmaTek · MDose
Version importée: 4b66536936ed
État de publication: Révision clinique en cours

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